Publications (2000-)


2015- / 2010-2014 / 2005-2009 / 2000-2004





Miyanaga, A.; Cieślak, J.; Shinohara, Y.; Kudo, F.; Eguchi, T. The Crystal Structure of Adenylation Enzyme VinN Reveals a Unique β-Amino Acid Recognition Mechanism. J. Biol. Chem., 2014, 289, 31448-31457.


Kudo, F.; Hoshi, S.; Kawashima, T.; Kamachi, T.; Eguchi, T. Characterization of a Radical S-Adenosyl-L-methionine Epimerase, NeoN, in the Last Step of Neomycin B Biosynthesis. J. Am. Chem. Soc., 2014, 136, 13909-13915.



工藤史貴、宮永顕正、江口正、 β-アミノ酸含有マクロラクタム抗生物質の生合成. 化学と生物、2014, 52, 830-835.


江口正、微生物二次代謝産物生合成の精密解析. The Japanese Journal of Antibiotics, 2014, 67, 253-263.


Kudo, F.; Miyanaga, A.; Eguchi, T. Biosynthesis of Natural Products containing β-Amino Acids. Nat. Prod. Rep., 2014, 31, 1056-1073.



Shinohara, Y.; Miyanaga, A.; Kudo, F.; Eguchi, T. The Crystal Structure of the Amidohydrolase VinJ Shows a Unique Hydrophobic Tunnel for its Interaction with Polyketide Substrates. FEBS Lett., 2014, 588, 995-1000.


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Koide, M.; Miyanaga, A.; Kudo, F.; Eguchi, T. Characterization of Polyphosphate Glucokinase SCO5059 from Streptomyces coelicolor A3(2). Biosci. Biotechnol. Biochem., 2013, 77, 2322-2324.



Amagai, K.; Takaku, R.; Kudo, F.; Eguchi, T. A Unique Amino Transfer Mechanism for Constructing the β-Amino Fatty Acid Starter Unit in the Biosynthesis of Macrolactam Antibiotic Cremimycin. ChemBioChem, 2013, 14, 1998-2006.



Takaishi,M.; Kudo, F.; Eguch, T. Identification of Incednine Biosynthetic Gene Cluster: Characterization of Novel β-Glutamate-β-decarboxylase IdnL3. J. Antibiot., 2013, 66, 691-699.



Hirayama, A.; Eguchi, T.; Kudo,F. A Single PLP-Dependent Enzyme PctV Catalyzes the Transformation of 3-Dehydroshikimate into 3-Aminobenzoate in the Biosynthesis of Pactamycin. ChemBioChem, 2013, 14, 1198-1203.



Itagaki, S.; Haga, M.; Oikawa, Y.; Sakoda, A.; Ohke, Y.; Sawada, H.; Eguchi, T.; Tamega, H.Difference on the Roles of of Glutamine Amidotransferase Subunit of Pyridoxal 5'-Phosphate Synthase between Bacillus circulans and Bacillus subtilis. Biosci. Biotechnol. Biochem., 2013, 77, 1482-1485.



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Takaishi, M.; Kudo, F.; Eguchi, T. A Unique Pathway for the 3-Aminobutyrate Starter Unit from L-Glutamate through β-Glutamate during Biosynthesis of the 24-Membered Macrolactam Antibiotic, Incednine. Org. Lett., 2012, 14, 4591-4593.



Fukuda, H.; Nishiyama, Y.; Nakamura, N.; Ohno, Y.; Eguchi, T.; Iwabuchi, Y.; Usui, T.; Kanoh, N. Synthesis and Structure-Activity Relationship of Vicenistatin, a Cytotoxic 20-Membered Macrolactam Glycoside. Chem. Asian J., 2012, 7, 2872-2881.



Kudo, F.; Yusaku Asou, Y.; Watanabe, M.; Kitayama,T.; Eguchi, T. Potent Oligomerization and Macrocyclization Activity of the Thioesterase Domain of Vicenistatin Polyketide Synthase. Synlett, 2012, 23, 1843-1846.



Sucipto, H.; Kudo, F.; Eguchi, T. The Last Step of Kanamycin Biosynthesis: Unique Deamination Reaction Catalyzed by the alpha-Ketoglutarate-dependent Nonheme Iron Dioxygenase KanJ and the NADPH Dependent Reductase KanK. Angew. Chem. Int. Ed., 2012, 51, 3428-3431.



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Shinohara, Y.; Kudo, F.; Eguchi, T. A Natural Protecting Group Strategy To Carry an Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antibiotics. J. Am. Chem. Soc., 2011, 133, 18134–18137.



Amagai, K.; Kudo, F.; Eguchi, T. Biosynthetic Pathway of Macrolactam Polyketide Antibiotic Cremimycin. Tetrahedron, 2011, 67, 8559-8563. 



Nakano, C.; Kudo, F.; Eguchi, T.; Ohnishi, Y. Genome Mining Reveals Two Novel Bacterial Sesquiterpene Cyclases: (-)-epi-α-Bisabolol and (-)-Germacradiene-4-ol Synthases from Streptomyces citricolor. ChemBioChem, 2011, 12, 2271-2275.




Nango, E.; Yamamoto, T.; Kumasaka, T.; Eguchi, T. Structure of Thermus thermophilus Homoisocitrate Dehydrogenase in Complex with a Designed Inhibitor. J. Biochem., 2011, 150, 607-614 .




Hoshino, T.; Nango, E.; Baba, S.; Eguchi, T.; Kumasaka, T. Crystallization and Preliminary X-ray Analysis of Isopentenyl Diphosphate Isomerase from Methanocaldococcus jannaschii. Acta Cryst., 2011, F67, 101-103.



Kudo, F.; Yonezawa, T.; Komatsubara, A.; Mizoue, M.; Eguchi, T. Cloning of the Biosynthetic Gene Cluster for Naphthoxanthene Antibiotic FD-594 from Streptomyces sp. TA-0256. J. Antibiot., 2011, 64, 123-132.



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Xu, Q.; Eguchi, T.; Mathews, I. I.; Rife, C. L.; Chiu, H-J.; Farr, C. L.; Feuerhelm, J.; Jaroszewski, L.; Klock, H. E.; Knuth, M. W.; Miller, M. D.; Weekes, D.; Elsliger, M-D.; Deacon, A. D.; Godzik, A.; Lesley, S. A.; Wilson. I. A., Insights into Substrate Specificity of Geranylgeranyl Reductases Revealed by the Structure of Digeranylgeranylglycerophospholipid Reductase from Thermoplasma acidophilum, an Essential Enzyme in the Biosynthesis of Archaeal Membrane Lipids. J. Mol. Biol., 2010, 404, 403-417.


Fukuda, H.; Nakamura, S.; Eguchi, T.; Iwabuchi, Y.; Kanoh. N. Concise Total Synthesis of Vicenistatin. Synlett, 2010, 2589-2592.



Kudo, F.; Motegi, A.; Mizoue, K.; Eguchi, T. Cloning and Characterization of the Biosynthetic Gene Cluster of 16-Membered Macrolide Antibiotic FD-891: Involvement of a Dual Functional Cytochrome P450 Monooxygenase Catalyzing Epoxidation and Hydroxylation. ChemBioChem, 2010, 11, 1574-1582.



Tamegai, H.; Sawada, H.; Nango, E.; Aoki, R.; Hirakawa, H.; Iino, T.; Eguchi T. Roles of 20 kDa Protein Associated with a Carbocycle-forming Enzyme Involved in Aminoglycoside Biosynthesis in Primary and Secondary Metabolism. Biosci. Biotechnol. Biochem., 2010, 74, 1215-1219.



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