Publications (2000-)




2015- / 2010-2014 / 2005-2009 / 2000-2004





Tohyama, S.; Eguchi, T.; Dhakal, R. P.; Akashi, T.; Otsuka, M.; Kakinuma, K. Genome-inspired Search for New Antibiotics. Isolation and Structure Determination of New 28-Membered Polyketide Macrolactones, Halstoctacosanolides A and B, from Streptomyces halstedii HC34. Tetrahedron, 2004, 60, 3999-4005.


Ogasawara, Y.; Katayama, K.; Minami, A.; Otsuka, M.; Eguchi, T.; Kakinuma K. Cloning, Sequencing, and Functional Analysis of the Biosynthetic Gene Cluster of Macrolactam Antibiotic Vicenistatin in Streptomyces halstedii. Chem. Biol, 2004, 11, 79-86.


Nango, E.; Eguchi, T.; Kakinuma, K. Active Site Mapping of 2-Deoxy-scyllo-inosose Synthase, the Key Starter Enzyme for the Biosynthesis of 2-Deoxystreptamine. Mechanism-Based Inhibition and Identification of Lysine-141 as the Entrapped Nucleophile. J. Org. Chem. 2004, 69, 593-600.


Eguchi, T.; Yamamoto, K.; Mizoue, K.; Kakinuma, K. Structure Revision of FD-891, a 16-Membered Macrolide Antibiotic. J. Antibiot.2004, 57, 156-157.


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Yukita, T.; Nishida, H.; Eguchi, T.; Kakinuma, K. Biosynthesis of (2R)-4-Amino-2-hydroxybutyric Acid, Unique and Biologically Significant Substituent in Butirosins. J. Antibiot. 2003, 56, 497-500.


Nango, E.; Kudo, F.; Eguchi, T.; Kakinuma, K. Reaction Stereochemistry of 2-Deoxy-scyllo-inosose Synthase, the Key Enzyme in the Biosynthesis of 2-Deoxystreptamine. Chem. Lett. 2003. 32, 438-439.


Eguchi, T.; Dekishima, Y.; Hamano, Y.; Dairi, T.; Seto, H.; Kakinuma, K. A New Approach for the Investigation of Isoprenoid Biosynthesis Featuring Pathway Switching, Deuterium Hyperlabeling, and 1H NMR Spectroscopy. The Reaction Mechanism of a Novel Streptomyces Diterpene Cyclase. J. Org. Chem. 2003, 68, 5433-5438.


Eguchi, T.; Nishimura, Y.; Kakinuma, K. Importance of the Isopropylidene Terminal of Geranylgeranyl Group for the Formation of Tetraether Lipid in Methanogenic Archaea. Tetrahedron Lett. 2003, 44, 3275-3279.


Eguchi, T.; Watanabe, E.; Kakinuma, K. Practical Enantioselective Synthesis of Fully Deuterated (R)-Mevalonolactone. Tetrahedron 2003, 59, 6035-6038.


Takei, K.; Dekishima, Y.; Eguchi, T.; Yamaya, T.; Sakakibara, H. A New Method for Enzymatic Preparation of Isopentenyladenine-type and trans-Zeatin-type Cytokinins with Radioisotope-labeling. J. Plant. Res. 2003, 116, 259-263.


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Tamegai, H.; Nango, E.; Koike-Takeshita, A.; Kudo, F.; Kakinuma, K. Significance of the 20-kDa Subunit of Heterodimeric 2-Deoxy-scyllo-inosose Synthase for the Biosynthesis of Butirosin Antibiotics in Bacillus circulans. Biosci. Biotechnol. Biochem. 2002, 66, 1538-1545.


Tamegai, H.; Nango, E.; Kuwahara, M.; Yamamoto, H.; Ota, Y.; Kuriki, H.; Eguchi, T.; Kakinuma, K. Identification of L-Glutamine: 2-deoxy-scyllo-inosose Aminotransferase Required for the Biosynthesis of Butirosin in Bacillus circulans. J. Antibiot. 2002, 55, 707-714.


Tamegai, H.; Eguchi, T.; Kakinuma, K. First Identification of Streptomyces Genes involved in the Biosynthesis of 2-Deoxystreptamine-containing Aminoglycoside Antibiotics: Genetic and Evolutionary Analysis of L-Glutamine:2-deoxy-scyllo-inosose Aminotransferase Genes. J. Antibiot. 2002, 55, 1016-1018.


Matsushima, Y.; Itoh, H.; Nakayama, T.; Horiuchi, S.; Eguchi, T.; Kakinuma, K. Enantioselective Total Synthesis of Vicenistatin, a Novel 20-Membered Macrocyclic Lactam Antitumor Antibiotic. Perkin 1 2002, 949-958.


Eguchi, T.; Sasaki, S.; Huang, Z.; Kakinuma, K. Importance of Specific Hydrogen-bond Donor-acceptor Interactions for the Key Carbocycle-forming Reaction Catalyzed by 2-Deoxy-scyllo-inosose Synthase in the Biosynthesis of 2-Deoxystreptamine-containing Aminocyclitol Antibiotics. J. Org. Chem. 2002, 67, 3979-3984.


Eguchi, T.; Kobayashi, K.; Uekusa, H.; Ohashi, Y.; Mizoue, K.; Matsushima, Y.; Kakinuma, K. Stereostructure of a Novel Cytotoxic 18-Membered Macrolactone Antibiotic FD-891. Org. Lett. 2002, 4, 3383-3386.


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Nishida, H.; Eguchi, T.; Kakinuma, K. Amino Acid Starter Unit in the Biosynthesis of Macrolactam Polyketide Antitumor Antibiotic Vicenistatin. Tetrahedron 2001, 57, 8237-8242.


Matsushima, Y.; Nakayama, T.; Tohyama, S.; Eguchi, T.; Kakinuma, K. Versatile Route to 2,6-Dideoxyamino Sugars from Non-sugar Materials: Syntheses of Vicenisamine and Kedarosamine. Perkin 1, 2001, 569-577.


Matsushima, Y.; Nakayama, T.; Fujita, M.; Bhandari, R.; Eguchi, T.; Shindo, K.; Kakinuma, K. Isolation and Structure Elucidation of Vicenistatin M, and Importance of the Vicenisamine Aminosugar for Exerting Cytotoxicity of Vicenistatin. J. Antibiot. 2001, 54, 211-219.


Kakinuma, K.; Dekishima, Y.; Matsushima, Y.; Eguchi, T.; Misawa, N.; Takagi, M.; Kuzuyama, T.; Seto, H. New Approach to Multiply Deuterated Isoprenoids Using Triply Engineered Escherichia coli and Its Potential as a Tool for Mechanistic Enzymology. J. Am. Chem. Soc. 2001, 123, 1238-1239.


Fujita, M.; Tamegai, H.; Eguchi, T.; Kakinuma, K. Novel Substrate Specificity of Designer 3-Isopropylmalate Dehydrogenase Derived from Thermus thermophilus HB8. Biosci. Biotechnol. Biochem. 2001, 65, 2695-2700.


Arakawa, K.; Eguchi, T.; Kakinuma, K. 36-Membered Macrocyclic Diether Lipid is Advantageous for Archaea to Thrive under the Extreme Thermal Environments. Bull. Chem. Soc. Jpn. 2001, 74, 347-356.


Arakawa, K.; Eguchi, T.; Kakinuma, K. Highly Thermostable Liposome from 72-Membered Macrocyclic Tetraether Lipid: Importance of 72-Membered Lipid for Archaea to Thrive under Hyperthermal Environments. Chem. Lett. 2001, 440-441.


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Otsuka, M.; Fujita, M.; Matsushima, Y.; Eguchi, T.; Shindo, K.; Kakinuma, K. Biosynthetic Pathway of Macrolactam Polyketide Glycoside Antitumor Antibiotic Vicenistatins. Tetrahedron 2000, 56, 8281-8286.


Ota, Y.; Tamegai, H.; Kudo, F.; Kuriki, H.; Koike-Takeshita, A.; Eguchi, T.; Kakinuma, K. Butirosin-biosynthetic Gene Cluster from Bacillus circulans. J. Antibiot. 2000, 53, 1158-1167.


Kakinuma, K.; Nango, E.; Kudo, F.; Matsushima, Y.; Eguchi, T. An Expeditious Chemo-enzymatic Route from Glucose to Catechol by the Use of 2-Deoxy-scyllo-inosose Synthase. Tetrahedron Lett. 2000, 41, 1935-1938.


Fujita, M.; Toyooka, Y.; Tamegai, H.; Eguchi, T.; Kakinuma, K. Arg-94 Is Crucial to the Catalysis of 3-Isopropylmalate Dehydrogenase from Thermus thermophilus HB8. J. Mol. Cat. B 2000, 9, 149-155.


Eguchi, T.; Takyo, H.; Morita, M.; Kakinuma, K.; Koga, Y. Unusual Double-bond Migration as a Plausible Key Reaction in the Biosynthesis of the Isoprenoidal Membrane Lipids of Methanogenic Archaea. Chem. Commun. 2000, 1545-1546.


Eguchi, T.; Arakawa, K.; Kakinuma, K.; Rapp, G.; Ghosh, S.; Nakatani, Y.; Ourisson, G. Giant Vesicles from 72-Membered Macrocyclic Archaeal Phospholipid Analogues: Initiation of Vesicle Formation by Molecular Recognition between Membrane Components. Chem. Eur. J. 2000, 6, 3351-3358.


Tanaka, K.; Stackebrandt, E.; Tohyama, S.; Eguchi, T. Desulfovirga adipica gen. nov., sp. nov., an Adipate-degrading, Gram-negative, Sulfate-reducing Bacterium. Int. J. Syst. Evol. Microbiol. 2000, 50, 639-644.


Dannenmuller, O.; Arakawa, K.; Eguchi, T.; Kakinuma, K.; Blanc, S.; Albrecht, A.-M.; Schmutz, M.; Nakatani, Y.; Ourisson, G. Membrane Properties of Archaeal Macrocyclic Diether Phospholipids. Chem. Eur. J. 2000, 6, 645-654.


Ogihara, J.; Kato, J.; Oishi, K.; Fujimoto, Y.; Eguchi, T. Production and Structural Analysis of PP-V, A Homologue of Monascorubramine, Produced by a New Isolate of Penicillium sp. J. Biosci. Bioeng. 2000, 90, 549-554.


Eguchi, T.; Kanai, S.; Kakinuma, K.; Okazaki, T.; Mizoue, K. Synthesis of NG-061 and Its Analogs, and Their Biological Evaluation as an Enhancer of Nerve Growth Factor. Chem. Pharm. Bull. 2000, 48. 1470-1473.


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