Publications (2000-)




2015- / 2010-2014 / 2005-2009 / 2000-2004





Kudo, F.; Sucipto, H.; Eguchi, T. Enzymatic Activity of a Glycosyltransferase KanM2 Encoded in the Kanamycin Biosynthetic Gene Cluster. J. Antibiot. 2009, 62, 707-710.




Nango, E.; Yamamoto, T.; Kumasaka, T.; Eguchi, T. Crystal Structure of 3-Isopropylmalate Dehydrogenase in Complex with NAD+ and a Designed Inhibitor. Bioorg. Med. Chem. 2009, 17, 7789-7794.



Kudo, F.; Kawashima, T.; Yokoyama, K.; Eguchi, T. Enzymatic Preparation of Neomycin C from Ribostamycin. J. Antibiot., 2009, 62, 643-646.



Kudo, F.; Eguchi, T. Biosynthetic Genes for Aminoglycoside Antibiotics. J. Antibiot. 2009, 62, 471-481.



Inaba, S.; Eguchi, T.; Motegi, A.; Mizoue, K.; Usui, T.; Nagai, K.; Kataoka, T. The Cytotoxic Macrolide FD-891 Induces Caspase-8-dependent Mitochondrial Release of Cytochrome c and Subsequent Apoptosis in Human Leukemia Jurkat Cells. J. Antibiot. 2009, 62, 507-512.



Kudo, F.; Eguchi, T. Biosynthetic Enzymes for the Aminoglycosides Butirosin and Neomycin. Methods Enzymol. 2009, 459, 493-519.



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Yokoyama, K.; Ohmori, D.; Kudo, F.; Eguchi, T. Mechanistic Study on the Reaction of a Radical SAM Dehydrogenase BtrN by Electron Paramagnetic Resonance Spectroscopy. Biochemistry 2008, 47, 8950-8960.


Nango, E.; Minami, A.; Kumasaka, T.; Eguchi, T. Crystallization and Preliminary X-ray Analysis of Vicenisaminyltransferase VinC. Acta Cryst. 2008, F64, 558-560.



Takaishi, M.; Kudo, F.; Eguchi, T. Biosynthetic Pathway of 24-Membered Macrolactam Glycoside Incednine. Tetrahedron 2008, 64, 6651-6656.


Lin,Y.; Volkman, J.; Nicholas, K. M.; Yamamoto, T.; Eguchi, T.; Nimmo, S. L.; West, A. H.; Cook, P. F. Chemical Mechanism of Homoisocitrate Dehydrogenase from Saccharomyces cerevisiae. Biochemistry 2008, 47, 4169-4180.




南後恵理子、江口正 糖質環化酵素の構造と機能の解明 "バイオマスから化学工業資 源へ" バイオサイエンスとインダストリー, 2008, 66, 61-64.


Yokoyama, K.; Yamamoto, Y.; Kudo, F.; Eguchi, T. Involvement of Two Distinct N-Acetylglucosaminyltransferases and a Dual-Function Deacetylase in Neomycin Biosynthesis. ChemBioChem 2008, 9, 865-869.



Yamamoto, T.; Eguchi, T. Thiahomoisocitrate: A Highly Potent Inhibitor of Homoisocitrate Dehydrogenase Involved in the α-Aminoadipate Pathway. Bioorg. Med. Chem. 2008, 16, 3372-3376.




Nango, E.; Kumasaka, T.; Hirayama, T.; Tanaka, N.; Eguchi, T. Structure of 2-Deoxy-scyllo-inosose Synthase, a Key Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminoglycoside Antibiotics, in Complex with a Mechanism-Based Inhibitor and NAD+. Proteins 2008, 70, 517-527.





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Yokoyama, K.; Numakura, M.; Kudo, F.; Ohmori, D.; Eguchi, T. Characterization and Mechanistic Study of a Radical SAM Dehydrogenase in the Biosynthesis of Butirosin. J. Am. Chem. Soc. 2007, 129, 15147-15155.




Kudo, F.; Kasama, Y.; Hirayama, T.; Eguchi, T. Cloning of the Pactamycin Biosynthetic Gene Cluster and Characterization of a Crucial Glycosyltransferase prior to a Unique Cyclopentane Ring Formation. J. Antibiot. 2007, 60, 492-503.



Hoshino, T.; Eguchi, T. Functional Analysis of Type 1 Isopentenyl Diphosphate Isomerase from Halobacterium sp. NRC-1. Biosci. Biotechnol. Biochem. 2007, 71, 2588-2591.




Kudo, F.; Fujii, T.; Kinoshita, S.; Eguchi, T. Unique O-Ribosylation in the Biosynthesis of Butirosin. Bioorg. Med. Chem. 2007, 15, 4360-4368.



Morii, H.; Eguchi, T.; Koga, Y. In vitro Biosynthesis of Ether-type Glycolipids in the Methanoarchaeon Methanothermobacter thermautotrophicus. J. Bacteriol. 2007, 189, 4053-4061.


Minami, A.; Eguchi, T. Substrate Flexibility of Vicenisaminyltransferase VinC involved in the Biosynthesis of Vicenistatin. J. Am. Chem. Soc. 2007, 129, 5102-5107.




Fraser, P. D.; Enfissi, E. M. A.; Goodfellow, M.; Eguchi, T.; Bramley, P. M. Metabolite Profiling of Plant Carotenoids using the Matrix-assisted Laser Desorption Ionization Time-of-flight Mass Spectrometry. Plant J. 2007, 49, 552-564.




Nishimura, Y.; Eguchi, T. Stereochemistry of Reduction in Digeranylgeranylglycerophospholipid Reductase Involved in the Biosynthesis of Archaeal Membrane Lipids from Thermoplasma acidophilum. Bioorg. Chem. 2007, 35, 276-283.



Hirayama, T.; Kudo, F.; Huang, Z.; Eguchi, T. Role of Glutamate 243 in the Active Site of 2-Deoxy-scyllo-inosose Synthase from Bacilllus circulans. Bioorg. Med. Chem. 2007, 15, 418-423.




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Hirayama, T.; Tamegai, H.; Kudo, F.; Kojima, K.; Kakinuma, K.; Eguchi, T. Biosynthesis of 2-Deoxystreptamine-containing Antibiotics in Streptoalloteichus hindudtanus JCM 3268: Characterization of 2-Deoxy-scyllo-inosose Synthase. J. Antibiot. 2006, 59, 358-361.




Hoshino, T.; Tamegai, H.; Kakinuma, K.; Eguchi, T. Inhibition of Type 2 Isopentenyl Diphosphate Isomerase from Methanocaldococcus jannaschii by a Mechanism-based Inhibitor of Type 1 Isopentenyl Diphosphate Isomerase. Bioorg. Med. Chem. 2006, 14, 6555-6559.



Nishimura, Y.; Eguchi, T. Biosynthesis of Archaeal Membrane Lipids: Digeranylgeranylglycerophospholipid Reductase of the Thermoacidophilic Archaeon Thermoplasma acidophilum. J. Biochem. 2006, 139, 1073-1081.



Tohyama, S.; Kakinuma, K.: Eguchi, T. The Complete Biosynthetic Gene Cluster of the 28-Membered Polyketide Macrolactones, Halstoctacosanolides, from Streptomyces halstedii HC34. J. Antibiot. 2006, 59, 44-52.



Kudo, F.; Kitayama, T.; Kakinuma, K.; Eguchi, T. Macrolactam Formation Catalyzed by the Thioesterase Domain of the Vicenistatin Polyketide Synthase. Tetrahedron Lett. 2006, 47, 1529-1532.


工藤史貴、江口正 天然有機化合物の生合成に学ぶ ~ア ミノグリコシド抗生物質生合成研究の進歩~ 化学と生物, 2006, 44, 49-55.


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Kudo, F.; Yamamoto, Y.; Yokoyama, K.; Eguchi, T.; Kakinuma, K. Biosynthesis of 2-Deoxystreptamine by Three Crucial Enzymes in Streptomyces fradiae NRBC 12773. J. Antibiot. 2005, 58, 766-774.



Eguchi, T. Mevalonolactone-d9; A Versatile Tool for Biosynthetic Study of Isoprenoids. Synthesis and Its Application. J. Synth. Org. Chem. Jpn. 2005, 63, 1069-1079.



Minami, A.; Kakinuma, K.; Eguchi, T. Aglycon Switch Approach toward Unnatural Glycosides from Natural Glycoside with Glycosyltransferase VinC. Tetrahedron Lett. 2005, 46, 6187-6190.




Ogasawara, Y.; Kakinuma, K.; Eguchi, T. Involvement of Glutamate Mutase in the Biosynthesis of the Unique Starter Unit of the Macrolactam Polyketide Antibiotic Vicenistatin. J. Antibiot. 2005, 58, 468-472.



Nango, E.; Kumasaka, T.; Sato, T.; Tanaka, N.; Kakinuma, K.; Eguchi, T. Crystallization and X-ray Analysis of 2-Deoxy-scyllo-inosose Synthase, the Key Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminoglycoside Antibiotics. Acta Cryst. 2005, F61, 709-711.


Kudo, F.; Numakura, M.; Tamegai, H.; Yamamoto, H.; Eguchi, T.; Kakinuma, K. Extended Sequence and Functional Analysis of the Butirosin Biosynthetic Gene Cluster in Bacillus circulans SANK 72073. J. Antibiot. 2005, 58, 373-379.



Minami, A.; Uchida, R.; Eguchi, T.; Kakinuma, K. Enzymatic Approach to Unnatural Glycosides with Diverse Aglycon Scaffolds Using Glycosyltransferase VinC. J. Am. Chem. Soc. 2005, 127, 6148-6149.




Yokoyama, K.; Kudo, F.; Kuwahara, M.; Inomata, K.; Tamegai, H.; Eguchi, T.; Kakinuma, K. Stereochemical Recognition of Doubly Functional Aminotransferase in 2-Deoxystreptamine Biosynthesis. J. Am. Chem. Soc. 2005, 127, 5869-5874.




Huang, Z.; Kakinuma, K.; Eguchi, T. Stereospecificity of Hydride Transfer in NAD(+)-catalyzed 2-Deoxy-scyllo-inosose Synthase, the Key Enzyme in the Biosynthesis of 2-Deoxystreptamine-containing Aminocyclitol Antibiotics. Bioorg. Chem. 2005, 33, 82-89.




Kudo, F.; Kawabe, K.; Kuriki, H.; Eguchi, T.; Kakinuma, K. A New Family of Glucose-1-phosphate/Glucosamine-1-phosphate Nucleotidylyltransferase in the Biosynthetic Pathways for Antibiotics. J. Am. Chem. Soc. 2005. 127, 1711-1718.




Eguchi, T.; Dekishima, Y.; Aizawa, H.; Tamegai, H.; Kakinuma, K.; Misawa, N.; Kuzuyama, T.; Seto, H. Preparation of Highly Deuterated Zeaxanthin, Lycopene, and [beta]-Carotene from Fully Deuterated Mevalonate using Engineered Escherichia coli. Tetrahedron 2005, 61, 2027-2035.




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